Rabbit Antibodies, LIMK2, and Custom Antibody Production

This blog will focus on three topics: rabbit antibodies, LIMK2, and custom antibody production. You can get the right solutions with superior customer service if you know where to look when shopping for custom antibody production. 

 

Did you know a rabbit spleen contains more B cells than that of a mouse?  Getting more B cells into the mix is important because they make antibodies, giving a better chance of finding the right clone for expansion.  In other words, that’s a good thing.

 

People often ask about antibodies with a wider range of epitopes, and rightfully so as they are quite important.  Immunoglobulin genes are found in rabbit antibodies which, in fact, fit an “extensive range of epitopes.”  Since the forms of a protein differ by just one amino acid residue, it results in a slight variation in structures. A rabbit’s immune response can develop antibodies that are better able to detect these subtle differences. On average, rabbit antibodies have a 10-100x higher affinity than mouse antibodies.

 

Two points on the matter: Reduced Immunodominance: When certain epitomes from the same antigen are more immunogenic than others, it is called immunodominance. This results in the immune system developing antibodies against the dominantly immunogenic epitope (but few antibodies against the other epitopes). Rabbits have less immunodominance than do mice.

 

 

More Small Molecules are Immunogenic in Rabbits: Another benefit ofchoosing a rabbit antibody is that the rabbit’s immune system is able to mount an immunogenic response to small molecules that are not very immunogenic to mice.

 

 

Rabbit antibodies might be the right way to go for your project.  The companies that produce them also produce products related to LIMK2, so they could be a real one-stop-shop for your research.  These are the offered services: polyclonal antibody development services, antigen preparation, vector construction to antibody expression, and purification. The main objective is to save the client time. Please visit www.capralogics.com for more details.