Significance of Chicken Antibodies

There are a lot of research and white papers available on chicken Antibodies. The isolation of Polyclonal antibodies from the immunized mammal’s serum has importantly contributed to scientific research. 

 

 

The state-of-art methods and technologies use the antibodies produced in hen-laid eggs. The technology and successful research also directed the growth of an alternative way to generate antibodies without stressing animals. Laying hens are extremely cheap as antibody generators compared to the other mammals earlier used for such research. The antibodies of chickens have biochemical benefits over the antibodies of mammals due to the avian and mammalian phylogenetic differences. The outcome of this potential difference is the decreased immunological examination of the background and increased sensitivity. 

 

 

Chicken antibodies are the most successful for custom antibody development since they do not activate the complement system of humans nor react with human and bacterial FC receptors, human anti-mouse IgG antibodies, or rheumatoid factors. Hence, chicken antibodies have so many advantages in contrast to mammalian antibodies. There are potential chances that it may replace mammalian antibodies in the future. Advantages of Chicken custom antibody development:

 

 

Long-lasting and Cost-effective: Most of the highly equipped labs show their chicken antibody preparations >90%IgY with a shelf-life of at least five years at 4˚C. Some labs also provide rabbit serum with limited life at 4˚C and sometimes lose their biological activities when frozen. Comparatively, the cost of rabbit antibodies (Protein A-purified) is much higher. 

 

 

No harm to the animal: Labs purify antibodies from eggs and not from serum. In contrast with rabbits, the serum is collected by preventing the animals and performing cardiac punctures or ear bleeds. These are the most painless and humane methods to produce antibodies. 

 

 

No Fc Domain insider the chicken IgY stem portion: This offers numerous benefits compared to rabbit IgGs:  A. It decreases the chances of getting false positives in reports and applications since it’s mammalian FC domain that muddles naturally occurring Anti-Fc Antibodies and rheumatoid factors. B. It does not muddle to mammalian Fc receptors and avoids non-precise muddling to cells stating such receptors. (E.g., Dendritic and macrophages cells) C. Also, it does not trigger a mammalian complement system that allows chicken antibodies IgYs in In-Vivo procedures. 

 

 

Nearly Infinite Quantities: It is possible to collect about 16-18 immune eggs from each hen, out of which around six immune eggs use to prepare IgY. The other 12 immune eggs are stored by the researchers in the refrigerator for emergency cases. If you are looking for an antibody production facility, you can check www.capralogics.com. It is a Hardwick, MA-based custom antibody development licensed service.